{"id":8,"date":"2024-09-16T12:29:24","date_gmt":"2024-09-16T15:29:24","guid":{"rendered":"http:\/\/ramirezlab.udec.cl\/?page_id=8"},"modified":"2025-09-12T11:53:30","modified_gmt":"2025-09-12T14:53:30","slug":"home","status":"publish","type":"page","link":"http:\/\/ramirezlab.udec.cl\/es\/","title":{"rendered":"Home"},"content":{"rendered":"
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<\/div>
RAM\u00cdREZ LAB<\/div>
Pharmacoinformatics
\n& Systems Pharmacology<\/div>
What we do<\/div><\/div><\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Bienvenidos<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A Ram\u00edrez Lab<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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We are a multidisciplinary group focused on the study of biomolecular systems by using theoretical and experimental approaches. We aim to use computational polypharmacology with wet lab analyses to strengthen the drug design and development processes. Our work involves collaboration with medicinal chemists, biochemists, and biologists, and we are part of the Pharmacology Department – Faculty of Biological Sciences at University of Concepci\u00f3n.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Active research areas<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Our laboratory spearheads innovative research across three key areas:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Systems pharmacology<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Computational biophysics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Multitarget drug design<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Together, these research avenues underscore our commitment to transcending traditional drug discovery paradigms, employing a synergistic blend of computational and experimental methodologies to pursue new avenues in the treatment of complex diseases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Latest publication<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Identification of druggable binding sites and small molecules as modulators
of TMC1.<\/p>

De-la-Torre, P.; Mart\u00ednez-Garc\u00eda, C.; Gratias, P.; Mun, M.; Santana, P.; Akyuz, N.; Gonz\u00e1lez, W.; Indzhykulian, A.;\u00a0Ram\u00edrez, D<\/p><\/div><\/div><\/div><\/div>

Communications Biology. 2025, 8:742. DOI: 10.1038\/s42003-025-07943-x<\/span><\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\u00a0<\/div><\/div><\/div><\/div>

Our ability to hear and maintain balance relies on the proper functioning of inner ear sensory hair cells, which translate mechanical stimuli into electrical signals via mechano-electrical transducer (MET) channels, composed of TMC1\/2 proteins. However, the therapeutic use of ototoxic drugs, such as aminoglycosides and cisplatin, which can enter hair cells through MET channels, often leads to profound auditory and vestibular dysfunction. To date, our understanding of how small-molecule modulators interact with TMCs remains limited, hampering the discovery of novel drugs. Here, we propose a structure-based drug screening approach, integrating 3D-pharmacophore modeling, molecular dynamics simulations of the TMC1 + CIB2 + TMIE complex, and experimental validation. Our pipeline successfully identified three potential drug-binding sites within the TMC1 pore, phospholipids, and key amino acids involved in the binding of several compounds, as well as FDA- approved drugs that reduced dye uptake in cultured cochlear explants. Our pipeline offers a broad application for discovering modulators for mechanosensitive ion channels.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Funding<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Principal Investigator <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Optimizaci\u00f3n de las interacciones ligando-prote\u00edna en el complejo de mecanotransducci\u00f3n de c\u00e9lulas ciliadas para la prevenci\u00f3n de ototoxicidad\u00a0 <\/strong>2023 \u2013 2024<\/p>

Chile – ANID – Concurso de Fomento a la Vinculaci\u00f3n Internacional para Instituciones de Investigaci\u00f3n Regionales No. FOVI240021.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Open Chemoinformatics <\/strong>2023 \u2013 2024<\/p>

Chile – Universidad de Concepci\u00f3n – Proyectos colabora.doc No. 2023014No. 2023014<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Multidisplinary Center for Biotechnology and Molecular Biology for Climate Change Adaptation in Forest Resources (CeBioCliF). <\/strong>2022 \u2013 2025<\/p>

Chile – ANID – Anillo regular de investigaci\u00f3n en ciencia y\/o tecnolog\u00eda No. ATE220043.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Towards systems pharmacology to design multi-target directed ligands as therapeutic alternatives for Alzheimer\u2019s disease<\/strong>. 2022 \u2013 2025<\/p>

Chile – ANID – Fondecyt Regular No. 1220656<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Let’s talk pharmacology!!! <\/strong>2022<\/p>

Chile – Universidad de Concepci\u00f3n – Proyectos internacionalizaci\u00f3n del pregrado UCO1966<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Identificaci\u00f3n de moduladores del canal i\u00f3nico TMC1 como alternativa terap\u00e9utica para el tratamiento de la sordera. <\/strong>2022 – 2023<\/p>

Chile – ANID – Concurso de Fomento a la Vinculaci\u00f3n Internacional para Instituciones de Investigaci\u00f3n Regionales No. FOVI210027<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Reposicionamiento de medicamentos para tratamiento de la pandemia por coronavirus (COVID-19). <\/strong>2021 – 2022<\/p>

Chile – ANID – Concurso para la Asignaci\u00f3n R\u00e1pida de Recursos para Proyectos de Investigaci\u00f3n sobre el Coronavirus (Covid-19). No. COVID0199<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Development of novel therapeutic alternatives for alcohol-use disorders: a multidisciplinary approach. <\/strong>2022 – 2025<\/p>

Chile – ANID – Anillo regular de investigaci\u00f3n en ciencia y\/o tecnolog\u00eda No. ACT210012<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Multi-target drug design against neurodegenerative diseases. <\/strong>2020 – 2021<\/p>

Chile – Conicyt \u2013 Programa de Cooperaci\u00f3n Internacional. Proyecto No. REDES190074.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Structural insights into the substrate specificity and transport mechanisms in the Nitrate\/Peptide transporter (NPF) family. <\/strong>2018 \u2013 2021.<\/p>

Chile – ANID – Fondecyt de iniciaci\u00f3n No. 11180604.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Co-investigator <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Crown ethers for selective modulation of the mechanoelectrical transduction channel of hair cells: computational and experimental insights.<\/strong> 2025 \u2013 2027.<\/p>

Chile – ANID – Sponsor – Fondecyt de Postdoctorado No. 3250793.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Uso de un Escape Room como recurso docente en las asignaturas de Farmacolog\u00eda.<\/strong> 2023 \u2013 2024<\/p>

Chile – Universidad de Concepci\u00f3n – Proyectos colabora.doc No. 2023015.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ori-tanpakushitsu: creaci\u00f3n de modelos tridimensionales para la comprensi\u00f3n de las fuerzas intermoleculares involucradas en la acci\u00f3n farmacol\u00f3gica. <\/strong>2023 \u2013 2024<\/p>

Chile – Universidad de Concepci\u00f3n – Proyectos colabora.doc No. 2023023.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ligand and structure-based polypharmacology of K+ channels from the nociceptive primary sensory neurons: an alternative in pain treatment.<\/strong> 2023 \u2013 2027<\/p>

Chile – ANID – Fondecyt Regular No. 1230446<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Development of an infectious process-activated protide with therapeutic potential for control of fish farming diseases. <\/strong>2023 \u2013 2027<\/p>

Chile – ANID – Fondecyt Regular No. 1231088<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Interdisciplinary generation of highly specific peptidic blockers of TASK-3 channel with antitumoral effect and targeting moiety for nanotherapeutics.<\/strong> 2023 \u2013 2027<\/p>

Chile – ANID – Fondecyt Regular No. 1230996<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Coupling artificial intelligence and neurosciences to enhance the pharmacological effects of tibolone on neuroglobin signaling in traumatic brain injury.<\/strong> 2021 \u2013 2024<\/p>

Ireland – Science Foundation Ireland \u2013 20\/FFP-P\/8649<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Actualizaci\u00f3n de los servicios de ANSEP (Astrocyte-neuron simulation environment platform<\/em>) bajo el estudio integrativo de enfermedades neurodegenerativas. <\/strong>2021 \u2013 2022.<\/p>

Colombia – COLCIENCIAS<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Target- and ligand-based drugs to control SARS-CoV-2 pandemic (CoV2Drugs). <\/strong>2020 \u2013 2021.<\/p>

Spain – Consejo Superior de Investigaciones Cient\u00edficas. No. CSIC-COV19-015<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Identificaci\u00f3n de reacciones controladoras de lipotoxicidad inducida por \u00e1cido palm\u00edtico en un modelo computacional multi\u00f3mico astrocitario. <\/strong>2020 \u2013 2022.<\/p>

Colombia – COLCIENCIAS – Call for proposals for the generation of new knowledge through scientific research projects in medical and health sciences. No. 67270<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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_ramirezlab_<\/h3>\n\t\t\t\t\t\t\t\t\t

We are a multidisciplinary group focused on pharmacoinformatics, drug design and system pharmacology at @udeconcepcion. Group leader @dmramirezs.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/a>\n<\/div>\n\n\t

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\n\t\t\n\t\t\t\u00a1Nuestras investigadoras cruzan fronteras! \ud83c\udde8\ud83c\uddf1\u2708\ufe0f\ud83c\uddea\ud83c\uddf8\n<\/span>\n\t\t\t\t\t\t\t\t\t\"\u00a1Nuestras\n\t\t<\/a>\n\t<\/div>\n<\/div>
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\n\t\t\n\t\t\t\u00a1Celebraci\u00f3n en Ram\u00edrezLab! \ud83d\udd2c\u2728\n\nQueremos felicitar<\/span>\n\t\t\t\n <\/path>\n <\/svg>\t\t\t\t\t\t\"\u00a1Celebraci\u00f3n\n\t\t<\/a>\n\t<\/div>\n<\/div>
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\n\t\t\n\t\t\t\u00a1Habemus Mag\u00edster en el Ramirez Lab! \ud83c\udf93\u2728\n\nQueremos <\/span>\n\t\t\t\n <\/path>\n <\/svg>\t\t\t\t\t\t\"\u00a1Habemus\n\t\t<\/a>\n\t<\/div>\n<\/div>
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\n\t\t\n\t\t\t\u00a1Nuevo paper publicado! \ud83d\udcc4\u2728\n\nEstamos muy felices de<\/span>\n\t\t\t\t\t\t\t\t\t\"\u00a1Nuevo\n\t\t<\/a>\n\t<\/div>\n<\/div>\t<\/div>\n\n\t
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RAM\u00cdREZ LABPharmacoinformatics & Systems PharmacologyWhat we do Welcome to Ram\u00edrez Lab We are a multidisciplinary group focused on the study of biomolecular systems by using theoretical and experimental approaches. We aim to use computational polypharmacology with wet lab analyses to strengthen the drug design and development processes. Our work involves collaboration with medicinal chemists, biochemists, […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/ramirezlab.udec.cl\/es\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/ramirezlab.udec.cl\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/ramirezlab.udec.cl\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/ramirezlab.udec.cl\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/ramirezlab.udec.cl\/es\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":439,"href":"http:\/\/ramirezlab.udec.cl\/es\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":1869,"href":"http:\/\/ramirezlab.udec.cl\/es\/wp-json\/wp\/v2\/pages\/8\/revisions\/1869"}],"wp:attachment":[{"href":"http:\/\/ramirezlab.udec.cl\/es\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}